abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies over the world. Alpha-fetoprotein (AFP) is an oncofetal protein during HCC development, which could generate weaker and less reproducible antitumor protection, and may serve as a target for immunotherapy. Therefore, it is imperative to enhance its i...

journal_title：Neoplasma

authors： Li Z,Wang XP,Lin HP,Xu B,Zhao Q,Qi BN,Yang YX,Wang ZR

更新日期：2015-01-01 00:00:00

abstract：:Factors influencing circulating miRNA as a diagnostic marker of hepatocellular carcinoma (HCC) are still unknown. We used two kits to extract total RNA of 90 paired serum and plasma samples of volunteers in different statuses including healthy, hepatitis, cirrhosis and HCC. U6, miR-183 and cel-miR-39 expression levels...

journal_title：Neoplasma

authors： Wang Y,Liang Z,Gao Y,Zhai D,Rao Q,Shi W,Yang B,Jing L,Guo H,Liu T,Liu J,DU Z

更新日期：2015-01-01 00:00:00

abstract：:The therapeutic potential of cisplatin in ovarian cancer treatment is restricted by the occurrence of cellular resistance. We aimed to explore the role of SRPK1 in cisplatin resistance related to the long non-coding RNA UCA1 in ovarian cancer cell.Totally, 24 ovarian cancer tissues and 16 normal tissues were used to a...

journal_title：Neoplasma

authors： Wang F,Zhou J,Xie X,Hu J,Chen L,Hu Q,Guo H,Yu C

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The current study aimed to evaluate the efficacy of sorafenib-based combined therapy against hepatocellular carcinoma (HCC). HepG2 cells were exposed to sorafenib, irinotecan, and oxaliplatin and then subjected to MTT assay to determine chemosensitivity. Flow cytometry was used to examine cell cycle distribu...

journal_title：Neoplasma

authors： Wang Z,Zhao Z,Wu T,Song L,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known abo...

journal_title：Neoplasma

authors： Han L,Liu W,Chen Y,Wu H,Zhang Y,Jiang B

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Survivin is highly expressed in human gastric cancer and correlated with chemoresistance and poor prognosis. In this study, we explored the effect of adeno-associated virus (AAV)-mediated survivin dominant mutant Thr34Ala (rAAV-Sur-Mut(T34A)) on gastric cancer growth. AAV-Sur-Mut (T34A) virus was generated a...

journal_title：Neoplasma

authors： Dang SC,Feng S,Wang PJ,Cui L,Qu JG,Zhang JX

更新日期：2015-01-01 00:00:00

abstract：:Carcinoma of oral cavity have a high risk of recurrence after initial treatment with surgery, radiotherapy, surgery with adjuvant radiotherapy, or radio-chemotherapy.The present study investigated the changes in expression, activity and regulation of matrix metalloproteinases (MMP) -2 and -9 in oral squamous cell carc...

journal_title：Neoplasma

authors： Nanda DP,Dutta K,Ganguly KK,Hajra S,Mandal SS,Biswas J,Sinha D

更新日期：2014-01-01 00:00:00

abstract：:Studies have shown that Annexin A2 (ANXA2) is related with tumor proliferation, apoptosis, differentiation, invasion, migration, and drug resistance. The purpose of this study was to investigate the role and its mechanisms of ANXA2 in multi-drug-resistance (MDR) in gastric cancer. ANXA2 expression in both gastric canc...

journal_title：Neoplasma

authors： Zhang ZD,Li Y,Fan Q,Zhao B,Tan B,Zhao XF

更新日期：2014-01-01 00:00:00

abstract：:The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...

journal_title：Neoplasma

authors： Imai H,Takahashi T,Mori K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Nakajima T,Yamamoto N

更新日期：2014-01-01 00:00:00

abstract：:Increased expression of STMN1 has been observed in many tumor forms, but its expression and potential biological role in pancreatic cancer is still unknown. In this study, we demonstrated that STMN1 was expressed to a large extent in pancreatic cancer tissues and cell lines as compared to normal pancreatic tissues. Su...

journal_title：Neoplasma

authors： Li J,Hu GH,Kong FJ,Wu KM,He B,Song K,Sun WJ

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:Expression patterns of proteins involved in serine and glycine metabolism, and correlations of these patterns with clinicopathologic factors in phyllodes tumor were investigated. Tissue microarrays were prepared from 203 phyllodes tumors (PT) and stained with antibodies specific for glycine decarboxylase (GL...

journal_title：Neoplasma

authors： Kwon JE,Kim DH,Jung WH,Koo JS

更新日期：2014-01-01 00:00:00

abstract：:Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cel...

journal_title：Neoplasma

authors： Li Y,Tan BB,Zhao Q,Fan LQ,Wang D,Liu Y

更新日期：2014-01-01 00:00:00

abstract：:MSH-PE38KDEL is a chimeric molecule composed of MSH, and fused to a truncated mutant form of Pseudomonas exotoxin (PE38KDEL). Our study aims to evaluate the specific cytotoxicity of recombinant immunotoxin MSH-PE38KDEL on melanoma cells A875 and B16 in vitro, as well as its inhibition of metastatic melanoma in vivo. M...

journal_title：Neoplasma

authors： Hui Q,Ma J,Song J,Liu Z,Ren H,Jiang W,Wang Y,Xu Y,Guo D,Zhang X,Lu S

更新日期：2014-01-01 00:00:00

abstract：:The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer. Meta-analysis was employed to investigate the association between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer.A total of 32 comparative st...

journal_title：Neoplasma

authors： Lee YH,Song GG

更新日期：2014-01-01 00:00:00

abstract：:The persistent hyperinsulinemic hypoglycemia may be caused either by a solitary tumor of the pancreas secreting excessive amount of insulin, known as insulinoma or, rarely, by nesidioblastosis. Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults. The incidence of nesidioblastosis in ...

journal_title：Neoplasma

authors： Dravecka I,Lazurova I

更新日期：2014-01-01 00:00:00

abstract：:Leucine-rich repeat-containing G protein-coupled receptor 5(LGR5) was identified as the stem cell marker of colon cancer stem cells(CSCs),which were considered as the main criminal cells initiation and reinitiation of colon cancer. We intended to demonstrate and further explain the relationship between LGR5 and colon ...

journal_title：Neoplasma

authors： Liu Z,Dai W,Jiang L,Cheng Y

更新日期：2014-01-01 00:00:00

abstract：:Cervical cancer is a multifactorial disease involving a complex interplay between genetic and environmental factors. An important role of HIF-1α in cervical cancer carcinogenesis has been studied by multiple researches. We hypothesized that there is a possible association between HIF-1α gene polymorphisms and the risk...

journal_title：Neoplasma

authors： Fu SL,Miao J,Ding B,Wang XL,Cheng WJ,Dai HH,Han SP

更新日期：2014-01-01 00:00:00

abstract：:Overexpressed Wilms tumor gene 1 (WT1) has been found in a majority of patients with acute myeloid leukemia (AML). The aim of this study was to confirm the applicability of WT1 expression measurement as a marker of minimal residual disease (MRD). The expression of WT1 gene was measured by real-time polymerase chain re...

journal_title：Neoplasma

authors： Polak J,Hajkova H,Haskovec C,Cechova H,Marinov I,Mikulenkova D,Markova J,Markova M,Vitek A,Valkova V

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological pr...

journal_title：Neoplasma

authors： Kucerova L,Skolekova S

更新日期：2013-01-01 00:00:00

abstract：:Podoplanin (D2-40) was shown to be expressed in cancer-associated fibroblasts (CAFs) of various malignancies. The study aimed at examining its impact on angiogenesis and lymphangiogenesis markers in invasive ductal carcinoma of the breast (IDC). The studies were performed on 104 archival cases of IDC using immunohisto...

journal_title：Neoplasma

authors： Pula B,Wojnar A,Witkiewicz W,Dziegiel P,Podhorska-Okolow M

更新日期：2013-01-01 00:00:00

abstract：:Electronic portal imaging (EPI) is commonly used to identify and correct for inter-fraction variability in tangential breast irradiation. Based on the institutional policy, EPI registration is performed by either radiation oncologist or therapist. Little data is available on the inter-observer agreement in EPI registr...

journal_title：Neoplasma

authors： Jereczek-Fossa BA,Santoro L,Colangione SP,Morselli L,Fodor C,Vischioni B,Rozza D,Leppa A,Cambria R,Leonardi MC,Morra A,Baroni G,Zurrida S,Orecchia R

更新日期：2013-01-01 00:00:00

abstract：:Recent studies have shown an indirect link between platelet count and blood vessel metastasis, but this association with lymphatic vessels metastasis has not been established in NSCLC. So we investigated whether an association exists between preoperative platelet count and lymph node metastasis in NSCLC patients. Betw...

journal_title：Neoplasma

authors： Liu HB,Gu XL,Ma XQ,Lv TF,Wu Y,Xiao YY,Yuan DM,Li YF,Song Y

更新日期：2013-01-01 00:00:00

abstract：:To date, epidemiological studies have assessed the association between Toll-like receptor 2 (TLR2) gene polymorphisms and cancer risk. However, the results of these studies remain controversial. We aimed to examine the associations between three SNPs (Delta22, rs3804099 and rs3804100) of TLR2 gene and cancer risk by c...

journal_title：Neoplasma

authors： Wang X,Li J,Xie W,Zhang W,Chang Y

更新日期：2013-01-01 00:00:00

abstract：:Molecular targeted therapy based on tyrosine kinase inhibitors, directed at the epidermal growth factor receptor (EGFR) is one of novel options for management of NSCLC. Erlotinib is EGFR tyrosine kinase inhibitor used for treatment of the advanced NSCLC. This presented study is focused on comparison of erlotinib and c...

journal_title：Neoplasma

authors： Fiala O,Pesek M,Finek J,Krejci J,Bortlicek Z,Benesova L,Minarik M

更新日期：2013-01-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease1 (APE1), which has the dual functions of DNA repair and redox regulation, is considered to be a promising potential target in cancer treatment. Microarray and qRT-PCR were used to confirm the change of miRNA followed by analysis with comprehensive bioinformatics-based analysis. Both ...

journal_title：Neoplasma

authors： Dai N,Zhong ZY,Cun YP,Qing Y,Chen Ch,Jiang P,Li MX,Wang D

更新日期：2013-01-01 00:00:00

abstract：:Optic pathway gliomas (OPG) occur in 15% of patients with neurofibromatosis type 1 (NF1; OMIM 162200). Genotype-phenotype correlations in patients with NF1 may help to determine the risk group for developing complications such as OPG in coincidence with other NF1.features. We evaluated 52 patients with NF1 (25 with OP...

journal_title：Neoplasma

authors： Bolcekova A,Nemethova M,Zatkova A,Hlinkova K,Pozgayova S,Hlavata A,Kadasi L,Durovcikova D,Gerinec A,Husakova K,Pavlovicova Z,Holobrada M,Kovacs L,Ilencikova D

更新日期：2013-01-01 00:00:00

abstract：:Few studies to date have reported on the development and application of a nanobiosensor based on localized surface plasmon resonance (LSPR) for detecting gene mutations. This study aimed to develop a novel LSPR biosensor used for detecting p53 mutation. Nanosphere lithography was used to fabricate the silver nanoparti...

journal_title：Neoplasma

authors： Duan RQ,Yuan JL,Yang H,Luo XG,Xi MR

更新日期：2012-01-01 00:00:00

abstract：:Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...

journal_title：Neoplasma

authors： Sivonova MK,Dobrota D,Matakova T,Dusenka R,Grobarcikova S,Habala V,Salagovic J,Tajtakova M,Pidanicova A,Valansky L,Lachvacs L,Kliment J Jr,Nagy V,Kliment J

更新日期：2012-01-01 00:00:00

abstract：:Genomic, epigenetic and expression alterations of WW domain containing oxidoreductase (WWOX) have been implicated in multiple tumor types. The current study was designed to examine the expression of WWOX in tumor tissues of human bladder transitional cell carcinoma (BTCC) and the influence of cigarette smoke extract (...

journal_title：Neoplasma

authors： Yang W,Cui S,Ma J,Lu Q,Kong C,Liu T,Sun Z

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:In a phase II clinical study, pretreated multiple myeloma patients with relapsing or stable disease received autologous anticancer vaccine containing dendritic cells loaded with Id-protein. Patients received a total of 6 vaccine doses intradermally in monthly intervals. No clinical responses were observed. D...

journal_title：Neoplasma

authors： Zahradova L,Mollova K,Ocadlikova D,Kovarova L,Adam Z,Krejci M,Pour L,Krivanova A,Sandecka V,Hajek R

更新日期：2012-01-01 00:00:00

abstract：:The flavonol aglycone isorhamnetin shows anti-proliferative activity in a variety of cancer cells. Previous work, from our laboratory showed that isorhamnetin inhibits the proliferation of human esophageal squamous carcinoma Eca-109 cells in vitro, but only after 72 h of exposure. This led us to propose that isorhamne...

journal_title：Neoplasma

authors： Shi C,Fan LY,Cai Z,Liu YY,Yang CL

更新日期：2012-01-01 00:00:00

abstract：:The aim of the study was to evaluate the expression of activated mammalian rapamycin (mTOR) and its downstream effectors, phosphorylated p70 ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1), in intrahepatic cholangiocarcinomas (ICC), in order to strengthen the rational...

journal_title：Neoplasma

authors： Wang Z,Zheng T,Wu Q,Wang J,Wu C,Wang J

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To explore the expression of the TRAV gene in peripheral blood mononuclear cells (PBMCs) and in tumor-infiltrating lymphocytes (TILs) in the patients with breast cancer using a DNA melting curve (FQ-PCR) technique for T cell receptor (TCR) alpha chain CDR3 spectratyping. Peripheral blood samples and tissue samp...

journal_title：Neoplasma

authors： He XY,Yang WM,Tang WT,Ma R,Sun YP,Wang P,Yao XS

更新日期：2012-01-01 00:00:00

abstract：:Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. We recently found that TCF21 methylation level was significantly increased in clear cell renal cell carcinoma (ccRCC). The purpose of this study was to inve...

journal_title：Neoplasma

authors： Ye YW,Jiang ZM,Li WH,Li ZS,Han YH,Sun L,Wang Y,Xie J,Liu YC,Zhao J,Tang AF,Li XX,Guan ZC,Gui YT,Cai ZM

更新日期：2012-01-01 00:00:00

abstract：:This study aimed to investigate the effects of RhoGDIα knockdown on apoptosis and the chemosensitivity of lung cancer cells to paclitaxel. The signaling proteins involved were also assessed. RhoGDIα expression was assessed by RT-PCR, Western blotting and immunohistochemistry. Apoptosis was determined by flow cytometri...

journal_title：Neoplasma

authors： Rong F,Li W,Chen K,Li DM,Duan WM,Feng YZ,Li F,Zhou XW,Fan SJ,Liu Y,Tao M

更新日期：2012-01-01 00:00:00

abstract：:Cancer is a complex disease with interactions between normal and neoplastic cells. Since current therapies for cancer largely rely on drugs or radiation that kill dividing cells or block cell division, these treatments may have severe side effects on normal proliferating cells in patients with cancer. Recently, immuno...

journal_title：Neoplasma

authors： Zhou LT,Liu FY,Li Y,Peng YM,Liu YH,Li J

更新日期：2012-01-01 00:00:00

abstract：:It is hypothesized that "cancer stem cells" are responsible for the resistance to chemotherapy of cancer cells in ovarian cancers. The objective of the studies was to explore if the stem cell biomarkers could be used to predict the tumor chemotherapy-resistance in serous ovarian cancer patients. Expression of two puta...

journal_title：Neoplasma

authors： Qin Q,Sun Y,Fei M,Zhang J,Jia Y,Gu M,Xia R,Chen S,Deng A

更新日期：2012-01-01 00:00:00

abstract：:We evaluated the prognostic impact of chromosomal abnormalities as detected by interphase fluorescence in situ hybridization (iFISH) in 86 chronic lymphocytic leukemia (CLL) patients. Overall, 39 of 86 (45%) patients displayed one (35%) or more (10%) chromosomal abnormalities, del13q (31%) being more frequently detect...

journal_title：Neoplasma

authors： Giertlova M,Hajikova M,Vaskova J,Kafkova A,Stecova N,Mirossay L,Karabinos A,Tothova E,Sarissky M

更新日期：2011-01-01 00:00:00

abstract：:Olfactomedin 4 (OLFM4) is a member of olfactomedin domain-containing protein family. Human OLFM4 is preferentially expressed in the gastrointestinal tract (stomach, small intestine and colon), prostate, and bone marrow. Recent studies demonstrate that OLFM4 is involved in the establishment and/or development of some t...

journal_title：Neoplasma

authors： Yu L,Wang L,Chen S

更新日期：2011-01-01 00:00:00

abstract：:Nodal metastasis is an important prognostic indicator in head and neck cancers, including salivary carcinomas. In these, the risk for lymph node metastasis is variable and strongly associated with the tumor histologic type. The aim of the current study was to evaluate the lymphatic vessel density (LVD) and expressions...

journal_title：Neoplasma

authors： Mello MF,Costa AF,Freitas LL,Soares AB,Araujo VC,Tincani AJ,Martins AS,Altemani A

更新日期：2011-01-01 00:00:00